LipoDuo™ Iron

Redefining Iron Supplementation with Advanced Liposomal Delivery

LipoDuo™ Iron incorporates ferric pyrophosphate encapsulated within a phospholipid matrix, transforming it into a water-dispersible, highly bioavailable, and patient-friendly formulation. This innovative technology ensures targeted delivery, superior absorption, and enhanced stability, overcoming the challenges of traditional iron supplements

Key Advantages

Enhanced Bioavailability

Up to 3x better absorption compared to plain ferric pyrophosphate

Lipid-Encapsulated Delivery

Protects iron from dietary interactions, ensuring consistent absorption

Gentle on the Stomach

Minimizes gastrointestinal side effects such as nausea and constipation

Improved Stability

Resists degradation from heat, pH variations, and oxidation

Uniform Particle Size

Nano-sized particles (100–500 nm) enhance cellular uptake and ensure consistent dosing

Better Patient Compliance

Neutral taste and reduced side effects improve adherence

Visual Comparisons

Plain Ferric Pyrophosphate: Slow release in acidic and alkaline pH, indicating poor solubility.
LipoDuo™ Iron: Dual-phase release with a peak in acidic pH and sustained release in alkaline pH

• LipoDuo™ Iron demonstrates significantly enhanced cellular uptake in CACO2 cells, reaching up to 6 µg/mL compared to plain ferric pyrophosphate

Clinical Applications

Iron Deficiency Management

Improves hemoglobin and ferritin levels effectively with reduced dosage requirements

Enhanced Patient Tolerance

Addresses anemia with minimal gastrointestinal discomfort

Targeted Iron Delivery

Provides immediate and sustained iron absorption for consistent supplementation

Pregnancy-Safe Iron

Ideal for pregnancy-related iron deficiencies due to gentle absorption and high tolerability

Particle Size and Stability

Nano-sized particles (~320 nm) with narrow size distribution ensure predictable bioavailability and o Stable zeta potential (-45.4 mV) confirms robust colloidal stability

Dissolution Profile

Optimized dual-phase release enhances bioavailability in both gastric and intestinal conditions

Cell Line Studies

Superior cellular uptake and proliferation confirm LipoDuo™ Iron’s efficacy in supporting biological iron needs

Dispersion Comparison

LipoDuo™ Iron demonstrates uniform dispersion in aqueous solutions, highlighting its solubility advantages over plain iron